Buy EPO Online - Erythropoietin for Sale
Buy EPO (Erythropoietin)
Erythropoietin Abbreviated as EPO is a cytokine glycoprotein. It is also known as hemopoietin secreted by the liver and kidneys in response to hypoxia (deficiency in oxygen cellular access). Buy Erythropoietin (EPO) because it assists erythropoiesis, a process of production of red blood cells in the bone marrow. In turn, red blood cells enhance the oxygen-carrying capacity of human blood. 10mU/mL is the amount of erythropoietin secreted by kidneys to compensate for RBC turnover. An elevated level of this hormone up to 10,000 mU/mL is an alarming situation. It may result in chronic anemia and hypoxia. Buy EPO online as it helps production in kidney fibroblasts dominates during adulthood. During perinatal and fetal period liver EPO production dominates.
|Recombinant Human Erythropoietin (rhEPO) is a familiar performance-boosting agent. It is widely used by athletes to enhance their endurance. The mode of action of recombinant EPO is to increase the hemoglobin level in human blood thus enhancing its oxygen-carrying capacity. This oxygen serves as a fuel for an athlete’s muscle activity enhancement.|
Buy EPO - Recombinant Human Erythropoietin Therapy as an Advanced Treatment
Epoetin alpha (Binokrit and Eprex) and epoetin beta (Epostim, Erythropoietin Binnopharm, and Mircera) are the classic examples of erythropoiesis-stimulating agents (ESAs). This exogenous erythropoietin is produced by an advanced recombinant DNA technology and widely used in the treatment of chronic renal anemia, chemotherapy, perioperative surgical blood loss, antiviral drug treatment, and myelodysplastic syndrome. ESA therapy gives clinically significant results.
Recombinant Human Erythropoietin (rhEPO) is a familiar performance-boosting agent. Buy EPO because it is widely used by athletes to enhance their endurance. The mode of action of recombinant EPO is to increase the hemoglobin level in human blood thus enhancing its oxygen-carrying capacity. This oxygen serves as a fuel for an athlete’s muscle activity enhancement
History of EPO (Erythropoietin)
In 1905 Paul Carnot narrated that a hormone can regulate red blood cell production in the bone marrow. Paul Carnot and his co-workers observed the factors responsible for bloodletting. They presented a hypothesis of an increase in red blood cells by a homeotropic factor hemopoietin. The substance was named as erythropoietin by Eva Jalavisto and Eeva Bonsdorff. In 1977 it was purified as erythropoietin hormone. In 1983, Amgen Inc. introduced Epotein Alfa as the first rhEPO commercial product. It was isolated by introducing the human erythropoietin gene into Hamster ovarian cells. Afterward, variant alpha and beta formulations are introduced. In 1987 rhEPO proved itself as an effective remedy of anemia. In 1989 Us Food and Drug Administration approved the use of Epogen Hormone. Since 1990, s alpha-EPO and beta-EPO have been frequently administered. These can be used subcutaneously as well as intravenously.
In 2008 Roche appeared on canvas with an introductory third generation of erythropoietin. Mircera (epoetin beta-methoxy polyethylene glycol) is a dominant product with its remarkable features. Methoxy polyethylene glycol is a long chain structural part of the drug which ensures the longer half-life. Mircera has 20 times longer half-life than epoetin (a part of the drug) thus relaxes its user by giving long dose breaks.
How is it used and when are you required to test for an EPO?
Essentially, the erythropoietin (EPO) test can help find out the cause of anemia. Buy EPO injection as it can help to identify representatives for the hormone replacement with erythropoietin (e.g. folks with kidney disease). It is sometimes used to help identify the cause of far too many red blood cells (polycythemia) or as part of a bone marrow abnormality assessment.
These tests identify the concentration and severity of anemia and provide hints to healthcare practitioners as to the probable cause of anemia. Testing for erythropoietin is requested to help determine whether low EPO may cause and/or deteriorate the anemia.
For patients with chronic kidney disease, buy erythropoietin test may be ordered to determine the continuing ability of the kidneys to produce enough erythropoietin.
If a person has kidney disease that does not occur to be caused by iron deficiency, b12 vitamins or folic acid deficiency, decreased life cycle of red blood cells (RBCs; hemolytic anemia), or heavy bleeding, erythropoietin (EPO) test may be ordered. This may be regulated when the number of RBCs, hemoglobin, and hematocrit is increased and the number of reticulocytes is excessively normal or increased.
Erythropoietin has a half-life of 5 hours in human blood. It is a glycosylated growth hormone which triggers the differentiation of erythroid ancestors in the bone marrow. The half-life may vary in recombinant or endogenous versions.
Epoetin Mode of Action:
EPO (Erythropoietin) buy as it is a hormone required for erythropoiesis, a process that regulates red blood cell production in the human body. When your body deprives enough supply of oxygen at the tissue and cellular level, this hypoxic condition is treated with erythropoietin secretion. The kidney will release erythropoietin by targeting proerythroblasts, CFU-E, and basophilic erythroblast subsets. The basic function of erythropoietin is to approach RBC progenitors in the human bone marrow and to protect them from apoptosis (the process of cell death).
Erythropoietin binds to the erythropoietin receptor (EpoR) and executes its effects. EPO buy because it activates a JAK2 signaling flow by binding the erythropoietin receptor at the surface of red blood cells. There are different initiated routes like PIK3, STAT5, and Ras MAPK. The result is the survival, growth, and differentiation among erythroid cells. Erythroid progenitors are the localized sites as erythropoietin receptor with high-level expression. There is an investigative study that suggests the heart, kidney, nervous tissues, and muscles as nonspecific EPO receptors. In human beings, RBCs do not act as a localized receptor of erythropoietin and nonresponding to EPO. Neocytolysis is the process which shows an indirect effect of erythropoietin on red blood cells by elevating plasma EPO level.
Erythropoietin as Doping Agent
The use of erythropoietin in sports dates back circa 1977 when for the first-time pure erythropoietin was purified from human urine. In literature terms used for recombinant erythropoietin are r-HuEPO, rHuEPO, rEPO, and r-HuEPO. An overview of the use of this hormone in sports is
- (1985-1987)-EPO gene cloning was a success with the commercial launch of rEPO
- (1980-1990)-A lot of cyclist’s deaths because of buying EPO administration.
- 1988- EPO was listed as a doping agent by the International Ski Federation.
- 1989- The commercial use of buy EPO it's a drug that was approved by the Food and Drug Administration.
- 1990- International Olympic Committee banned the use of EPO.
- 1997- International Ski Federation and The International Cycling Union introduced a method of blood sampling and their doping test to ensure the health standards of sportsmen.
- 1998- France Cycling competition was the main highlighted event for the use of erythropoietin as a stamina boosting agent.
- 1999- In Sydney, a meeting on the blood EPO detection in Olympics was called.
Erythropoietin is a member of S2 group hormones, the hormones which are banned worldwide for therapy. The only advantage of its application in sports and clinically is its functionality. It increases human blood oxygen-carrying capacity by giving a boost to RBC number. As a doping agent, its goal is to supply energy to an athlete’s muscles.
Erythropoietin practically appeared on the canvas when it was artificially prepared from hamster ovarian cells. Recombinant EPO Recormon is chemically identical to human EPO with some structural differences. This renders a minute difference in the physicochemical properties of rEPO. In sports, doping is extensively used for cycling with endurance manifestation. In any kind of sports where extensive muscle energy is required e.g. cycling, swimming, skating, running and skinning, etc. erythropoietin therapy is practiced. The continuous application of buy EPO with assisted physical work gives stamina to its user.
EPO Doping Test
The current techniques used for doping tests are direct and indirect methods. The application of indirect arsenal for doping control is preferable because it requires a small amount of urine or blood sample. Administration of erythropoietin and afterward the determination of its (fibrinogen and fibrin) breakdown products in the urine sample is an effective tool for doping control. But recently we cannot rely on a single test to finally estimate the administration of exogenous erythropoietin.
What is the Normal EPO range?
The typical range per milliliter (mU / mL) is 2.3 to 18.4 milliunits. The normal ranges of values may vary slightly from one laboratory to another. Some laboratories use different measurements or test various samples. Discuss the meaning of your particular test result with your health care provider.
Secondary polycythemia can cause a higher EPO level. This is a red blood cell overproduction occurring in response to a particular situation such as low blood oxygen levels. The situation may occur at high velocities or, rarely, due to an EPO-releasing tumor.
Use by Endurance Athletes and Cyclists:
Erythropoietin — more generally referred to as the EPO — is a type of blood doping that really can greatly boost endurance for an athlete.
During the 2002 Tour de France, where entire Festina squad was disqualified after so many hundred doses of EPO and other illicit drugs were discovered in the team car. This was the first time when EPO was brought to the people's attention.
Buy EPO online widely used by cyclists because they have to do a lot of running and jogging and they need a lot of strength and stamina that will help them stay motivated.
This medication can be given as an injection, usually 1 to 3 times a week, underneath the skin and into a vein as prescribed by the doctor. Patients who obtain this drug may have a specific dosing schedule before the surgery. Patients with kidney dialysis should have this medication injected into a vein.
If you are taking this medication at home, learn all the instructions for preparation and use from your health care. The dosage is dependent on your medical condition, weight and therapeutic reaction. Blood testing will also be performed to verify how well this drug works and to determine the right dosage for you. For more info, check with your doctor.
Taking this drug frequently to make the most of it. It may take two to eight weeks to get your red blood cell count up. Buy EPO injection at our pharmacy.
Medical Applications of Erythropoietin
Erythropoietin is used as a therapeutic agent for the treatment of chronic kidney anemia. The widely used EPO drugs for treatment are Aranesp (darbepoetin alpha) and Epogen/Procrit (epoetin alpha). State of the art Recombinant DNA technology is practiced producing Recombinant Erythropoietin drugs. Other fields of clinical application are Ulcerative colitis, Crohn's disease, chemotherapy-induced anemia, and other chronic factors.
Side Effects of Erythropoietin
- Frequent use of Erythropoietin may offer the following risk factors subject to increased blood hemoglobin levels than 11g/dl.
- Myocardial infection/Heart attack
- Brain stroke
- Cancer recurrence
- Venous thromboembolism
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