Buy EPO Online - Erythropoietin for Sale
Buy EPO (Erythropoietin)
Erythropoietin Abbreviated as EPO is a cytokine glycoprotein. It is also known as hemopoietin secreted by the liver and kidneys in response to hypoxia (deficiency in oxygen cellular access). Buy erythropoietin or EPO because it assists erythropoiesis, a process of production of red blood cells in the bone marrow. In turn, red blood cells enhance the oxygen-carrying capacity of human blood. 10mU/mL is the amount of erythropoietin secreted by kidneys to compensate for RBC turnover. An elevated level of this hormone up to 10,000 mU/mL is an alarming situation. It may result in chronic anemia and hypoxia. Buying EPO online helps production in kidney fibroblasts dominates during adulthood. During perinatal and fetal period liver EPO production dominates.
|Recombinant Human Erythropoietin (rhEPO) is a familiar performance-boosting agent. It is widely used by athletes to enhance their endurance. The mode of action of recombinant EPO is to increase the hemoglobin level in human blood thus enhancing its oxygen-carrying capacity. This oxygen serves as a fuel for an athlete’s muscle activity enhancement.|
Buying EPO - Recombinant Human Erythropoietin Therapy as an Advanced Treatment
Epoetin alpha (Binokrit and Eprex) and epoetin beta (Epostim, Erythropoietin Binnopharm, and Mircera) are the classic examples of erythropoiesis-stimulating agents (ESAs). This exogenous erythropoietin is produced by an advanced recombinant DNA technology and widely used in the treatment of chronic renal anemia, chemotherapy, perioperative surgical blood loss, antiviral drug treatment, and myelodysplastic syndrome. ESA therapy gives clinically significant results.
Recombinant Human Erythropoietin (rhEPO) is a familiar performance-boosting agent. Buy EPO because it is widely used by athletes to enhance their endurance. The mode of action of recombinant EPO is to increase the hemoglobin level in human blood thus enhancing its oxygen-carrying capacity. This oxygen serves as a fuel for an athlete’s muscle activity enhancement
History of EPO (Erythropoietin)
In 1905 Paul Carnot narrated that a hormone can regulate red blood cell production in the bone marrow. Paul Carnot and his co-workers observed the factors responsible for bloodletting. They presented a hypothesis of an increase in red blood cells by a homeotropic factor hemopoietin. The substance was named as erythropoietin by Eva Jalavisto and Eeva Bonsdorff. In 1977 it was purified as erythropoietin hormone. In 1983, Amgen Inc. introduced Epotein Alfa as the first rhEPO commercial product. It was isolated by introducing the human erythropoietin gene into Hamster ovarian cells. Afterward, variant alpha and beta formulations are introduced. In 1987 rhEPO proved itself as an effective remedy of anemia. In 1989 Us Food and Drug Administration approved the use of Epogen Hormone. Since 1990, s alpha-EPO and beta-EPO have been frequently administered. These can be used subcutaneously as well as intravenously.
In 2008 Roche appeared on canvas with an introductory third generation of erythropoietin. Mircera (epoetin beta-methoxy polyethylene glycol) is a dominant product with its remarkable features. Methoxy polyethylene glycol is a long chain structural part of the drug which ensures the longer half-life. Mircera has 20 times longer half-life than epoetin (a part of the drug) thus relaxes its user by giving long dose breaks.
How is it used and when are you required to test for an EPO?
Essentially, the erythropoietin (EPO) test can help find out the cause of anemia. Buy EPO injection as it can help to identify representatives for the hormone replacement with erythropoietin (e.g. folks with kidney disease). It is sometimes used to help identify the cause of far too many red blood cells (polycythemia) or as part of a bone marrow abnormality assessment.
These tests identify the concentration and severity of anemia and provide hints to healthcare practitioners as to the probable cause of anemia. Testing for erythropoietin is requested to help determine whether low EPO may cause and/or deteriorate the anemia.
For patients with chronic kidney disease, an erythropoietin test may be ordered to determine the continuing ability of the kidneys to produce enough erythropoietin.
If a person has kidney disease that does not occur to be caused by iron deficiency, b12 vitamins or folic acid deficiency, decreased life cycle of red blood cells (RBCs; hemolytic anemia), or heavy bleeding, erythropoietin (EPO) test may be ordered. This may be regulated when the number of RBCs, hemoglobin, and hematocrit is increased and the number of reticulocytes is excessively normal or increased.
Erythropoietin has a half-life of 5 hours in human blood. It is a glycosylated growth hormone which triggers the differentiation of erythroid ancestors in the bone marrow. The half-life may vary in recombinant or endogenous versions.
Epoetin Mode of Action:
EPO a hormone required for erythropoiesis, a process that regulates red blood cell production in the human body. When your body deprives enough supply of oxygen at the tissue and cellular level, this hypoxic condition is treated with erythropoietin secretion. The kidney will release erythropoietin by targeting proerythroblasts, CFU-E, and basophilic erythroblast subsets. The basic function of erythropoietin is to approach RBC progenitors in the human bone marrow and to protect them from apoptosis (the process of cell death).
Erythropoietin binds to the erythropoietin receptor (EpoR) and executes its effects. Buy EPO because it activates a JAK2 signaling flow by binding the erythropoietin receptor at the surface of red blood cells. There are different initiated routes like PIK3, STAT5, and Ras MAPK. The result is the survival, growth, and differentiation among erythroid cells. Erythroid progenitors are the localized sites as erythropoietin receptor with high-level expression. There is an investigative study that suggests the heart, kidney, nervous tissues, and muscles as nonspecific EPO receptors. In human beings, RBCs do not act as a localized receptor of erythropoietin and nonresponding to EPO. Neocytolysis is the process which shows an indirect effect of erythropoietin on red blood cells by elevating plasma EPO level.
Erythropoietin as Doping Agent:
The use of erythropoietin in sports dates back circa 1977 when for the first-time pure erythropoietin was purified from human urine. In literature terms used for recombinant erythropoietin are r-HuEPO, rHuEPO, rEPO, and r-HuEPO. An overview of the use of this hormone in sports is
- (1985-1987)-EPO gene cloning was a success with the commercial launch of rEPO
- (1980-1990)-A lot of cyclist’s deaths because of buying EPO administration.
- 1988- EPO was listed as a doping agent by the International Ski Federation.
- 1989- The commercial use of buy EPO it's a drug that was approved by the Food and Drug Administration.
- 1990- International Olympic Committee banned the use of EPO.
- 1997- International Ski Federation and The International Cycling Union introduced a method of blood sampling and their doping test to ensure the health standards of sportsmen.
- 1998- France Cycling competition was the main highlighted event for the use of erythropoietin as a stamina boosting agent.
- 1999- In Sydney, a meeting on the blood EPO detection in Olympics was called.
Erythropoietin is a member of S2 group hormones, the hormones which are banned worldwide for therapy. The only advantage of its application in sports and clinically is its functionality. It increases human blood oxygen-carrying capacity by giving a boost to RBC number. As a doping agent, its goal is to supply energy to an athlete’s muscles.
Erythropoietin practically appeared on the canvas when it was artificially prepared from hamster ovarian cells. Recombinant EPO Recormon is chemically identical to human EPO with some structural differences. This renders a minute difference in the physicochemical properties of rEPO. In sports, doping is extensively used for cycling with endurance manifestation. In any kind of sports where extensive muscle energy is required e.g. cycling, swimming, skating, running and skinning, etc. erythropoietin therapy is practiced. The continuous application of buy EPO with assisted physical work gives stamina to its user.
EPO Doping Test:
The current techniques used for doping tests are direct and indirect methods. The application of indirect arsenal for doping control is preferable because it requires a small amount of urine or blood sample. Administration of erythropoietin and afterward the determination of its (fibrinogen and fibrin) breakdown products in the urine sample is an effective tool for doping control. But recently we cannot rely on a single test to finally estimate the administration of exogenous erythropoietin.
What is the Normal EPO range?
The typical range per milliliter (mU / mL) is 2.3 to 18.4 milliunits. The normal ranges of values may vary slightly from one laboratory to another. Some laboratories use different measurements or test various samples. Discuss the meaning of your particular test result with your health care provider.
Secondary polycythemia can cause a higher EPO level. This is a red blood cell overproduction occurring in response to a particular situation such as low blood oxygen levels. The situation may occur at high velocities or, rarely, due to an EPO-releasing tumor.
Use by Endurance Athletes and Cyclists:
Erythropoietin — more generally referred to as the EPO — is a type of blood doping that really can greatly boost endurance for an athlete.
During the 2002 Tour de France, where entire Festina squad was disqualified after so many hundred doses of EPO and other illicit drugs were discovered in the team car. This was the first time when EPO was brought to the people's attention.
EPO widely used by cyclists because they have to do a lot of running and jogging and they need a lot of strength and stamina that will help them stay motivated.
This medication can be given as an injection, usually 1 to 3 times a week, underneath the skin and into a vein as prescribed by the doctor. Patients who obtain this drug may have a specific dosing schedule before the surgery. Patients with kidney dialysis should have this medication injected into a vein.
If you are taking this medication at home, learn all the instructions for preparation and use from your health care. The dosage is dependent on your medical condition, weight, and therapeutic reaction. Blood testing will also be performed to verify how well this drug works and to determine the right dosage for you. For more info, check with your doctor.
Taking this drug frequently to make the most of it. It may take two to eight weeks to get your red blood cell count up.
Medical Applications of Erythropoietin:
Erythropoietin is used as a therapeutic agent for the treatment of chronic kidney anemia. The widely used EPO drugs for treatment are Aranesp (darbepoetin alpha) and Epogen/Procrit (epoetin alpha). State of the art Recombinant DNA technology is practiced producing Recombinant Erythropoietin drugs. Other fields of clinical application are Ulcerative colitis, Crohn's disease, chemotherapy-induced anemia, and other chronic factors.
Side Effects of Erythropoietin:
- Frequent use of Erythropoietin may offer the following risk factors subject to increased blood hemoglobin levels than 11g/dl.
- Myocardial infection/Heart attack
- Brain stroke
- Cancer recurrence
- Venous thromboembolism
(EPO) ERYTHROPOIETIN EXTENDED DESCRIPTION
Which diseases or problems does Erythropoietin treat or control by prescribed medication or injections?
In certain medical practices, erythropoietin is used. The most frequent use is in patients with kidney failure associated anemia (reduced blood count). They contain less than normal quantities of erythropoietin when the kidneys are not working properly, which can result in lower production of red blood cells, or anemia. Thus, chronic inflammation related to kidney infection may be treated by substituting the erythropoietin with an intravenous infusion of synthetic erythropoietin. Epogen or Procrit is currently a core component of therapy in kidney disease patients requiring dialysis to both prevent or treat anemia.
Can an individual with no medical disease or injury have a high level of Erythropoietin (EPO)?
Yeah. For example, erythropoietin is often used in athletes like cyclists (in the Tour de France), long-distance competitors, speed skateboarders, and Nordic (cross-country) mountaineers as a performance-enhancing medication. It is assumed that erythropoietin is especially helpful when used in these circumstances.
Recent research has shown that cyclists or athletes who have ingested EPO help improve their endurance and efficiency by 24%.
How should I take medication for the EPO?
Buying EPO medicines are safe to take with other drugs and can be used with any dialysis type. Drugs from the EPO can also be used for people with anemia but who have not begun dialysis.
Your doctor will determine how much medicine you need when he looks at your blood tests. You may need to change the medication dosage amount, and your doctor will guide you on what to do.
Why is a test conducted for Erythropoietin?
It can detect and quantify the erythropoietin hormone in the blood. An abnormal blood level of erythropoietin may indicate disorders of the bone marrow (such as hypoglycemia). Monitoring blood levels of erythropoietin is of concern when:
- Too little EPO may be blamed for very few red blood cells (anemia), in particular kidney-related anemia.
- Too much EPO may cause excessive red blood cells (hypoglycemia).
- Too much EPO may be evidence for a tumor in the kidneys.
- In a athlete, too much erythropoietin might suggest the abuse of erythropoietin.
What do patients need to remember before using Erythropoietin EPO?
Here are the few safety issues with EPO:
- EPO may raise the risk of endometrial cancer (the venous blood clots). A blood clot can split away from one location and move to the lung (pericardial effusion), where circulation can be blocked. Symptoms of clots include chest pain, nausea, soreness in the legs, and extreme headache, neck, or leg numbness or stiffness.
- EPO can cause blood cells to rise very high, putting the patient at an increased risk of heart failure, stroke, and death.
- EPO may trigger tumor growth in patients who've had cancer. If EPO is used for these purposes, they are stopped after the patient has completed chemotherapy.
- The medical practitioner will keep a keen eye on the counts of blood cells in the patient to ensure that they do not put him or her at an elevated risk. Depending on the health and condition of the patient the dosing may change.
What will happen if I have far too much Erythropoietin?
Excess erythropoietin results from prolonged low oxygen levels or rare erythropoietin-producing tumors. This causes a disorder called hypoglycemia which is a high count of red blood cells. Hypoglycemia isn't causing any effects in other cases. There are, however, other general and unspecific signs of fatigue, weakness, and nausea.
What will happen if I have too little erythropoietin?
If you have far less erythropoietin, typically caused by chronic kidney disease, less red blood cells will occur, and you will get anemia. Pharmaceutically, erythropoietin was made for the treatment of anemia that ultimately resulted from chronic kidney disease. This is also prescribed to patients of certain rarer cancer types.
This kind of erythropoietin medication or injection (known as blood doping) has been used by some elite athletes to enhance their performance, in particular, to increase stamina. Increasing your erythropoietin levels artificially produces more red blood cells, and thus increases the amount of oxygen that can be provided to tissues, especially muscles. That can enhance efficiency and performance.
Erythropoietin EPO Half-life:
Healthy volunteers or Athletes: Average half-life of healthy volunteers receiving an intravenous injection is around four hours. Children have been reported to have a half-life of about 6 hours.
Cancer patients undergoing cyclic cancer treatment: The average half-life after subcutaneous injection is 40 hours with a duration of 17 to 68 hours.
Adult and pediatric patients: Half-life elimination after intravenous administration differs from 4 to 15 hours, which in CRF patients is about 20 percent longer than in healthy individuals. The half-life is stated to be identical among adult patients receiving dialysis or otherwise.
How to Properly inject EPO injections?
EPO injection is typically administered by a physician in a hospital or clinic during a prescription for kidney dialysis. But injection medicines are sometimes used at home. If you are taking EPO at home, your doctor will show you how to administer the injections. Just make sure you understand exactly how to administer the drug.
If the drug is used at home:
- Every time you inject your medication use a new sterile needle and syringe.
- Also, don't use more of the medicine than your doctor prescribes you.
- The doctor will show the areas of your body where you can take this shot.
- If you are using the one-dose syringes, you may not be using all of the medication in each vial. Only use each vial once, and throw away any extra medicine. Don't leave the vial open.
- When you are using the vial, which has enough medication for more than one dose, put it back in the fridge after each use. Note the date you first used it on the vial and toss away any unused medicinal products after three weeks.
The EPO occasionally causes seizures, particularly during the first approximately 70 days of treatment. It is ideal during this time to avoid traveling, using machinery, or doing other tasks that could cause serious harm if a seizure occurs when you are performing them.
Never use this drug if you have an allergic reaction to hemoglobin or compounds obtained from human or animal cells.
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- MIRCERA (Epoetin beta)
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- Epostim (Epoetin beta, EPO, Erythropoietin)